Anti-inflammatory effects of tirzepatide: a systematic review and meta-analysis

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dc.contributor.authorWalter Masson
dc.contributor.authorMartín Lobo
dc.contributor.authorJuan P. Nogueira
dc.contributor.authorLeandro Barbagelata
dc.contributor.authorPedro Touzas
dc.contributor.author· Juan P. Frías
dc.date.accessioned2026-08-25T23:01:08Z
dc.date.available2026-08-25T23:01:08Z
dc.date.issued2025-08-25
dc.description.abstractTirzepatide, a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, has demonstrated substantial metabolic and weight-reduction benefits; however, its anti-inflammatory effects remain less established. This systematic review and meta-analysis, conducted according to PRISMA guidelines, included randomized clinical trials and observational studies evaluating changes in high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6). A random-effects model was applied. Tirzepatide significantly reduced hsCRP and IL-6 levels compared with placebo across different doses and study populations. These findings suggest that tirzepatide exerts significant anti-inflammatory effects, potentially contributing to its broader cardiometabolic benefits.
dc.description.sponsorshipTirzepatide; Inflammation; C-reactive protein; Interleukin-6; Cardiometabolic health.
dc.identifier.urihttp://repositorio.uia.ac.cr/handle/123456789/5128
dc.language.isoen
dc.titleAnti-inflammatory effects of tirzepatide: a systematic review and meta-analysis
dc.typeArticle
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